Conversation
Blood clots is due to blood solidification and unpredictable viscosity due to barriers affecting its fluidity; so it leads to the forming of edarling thrombocytes and you will activation off blood coagulation basis (8–10). For this reason, repairing blood viscosity and you will improving blood coagulation mode indexes has actually an enthusiastic crucial character throughout the reduction and remedy for DVT.
All of our research indicated that to own three days and you may 10 weeks after DVT acting, hemorheology and you will coagulation spiders have been an informed regarding the large-dosage folic acid and you can nutritional B12 category. Some profile keeps suggested you to Hcy was an effective blood clots-developing broker, and you may large Hcy you can expect to induce deep venous thrombosis (14–17). Simultaneously, plasma D-dimer has been proposed getting an effective forewarning means to possess blood clots and hypercoagulable condition (18,19). 10 days after DVT acting, i found that the amount out-of Hcy and you may D-dimer enhanced more on higher-dose group.
Thanks to histopathologic test, i found that 10 weeks immediately following DVT modeling the brand new higher-serving and low-dose organizations exhibited significant change in the alteration away from all the way down extremity strong venous thrombosis. Deep venous thrombosis off all the way down extremity which have color Doppler ultrasound diagnosis has many masters, particularly easy procedure, security and energy conserving, discount, repeatability and you will lead observation, in addition to recognition out-of related sores and you can bleeding has actually as much as blood vessels (20). All of our abilities and additionally revealed that immediately after DVT acting, the energetic rates from all the way down extremity strong venous thrombosis treatments for high-amount class is actually a hundred%. The results off color Doppler ultrasound diagnosis out-of DVT corresponded to all of our results when you look at the histopathologic test. That it validated the brand new feasibility and energy conserving of color Doppler ultrasound medical diagnosis to possess strong venous thrombosis of one’s straight down extremity.
In the sumin B12 has obvious therapeutic consequences from inside the a bunny design from DVT that have hyperhomocysteinemia. New higher-dosages we experimented with enhanced certain associated episodes, like the amounts of Hcy and you will D-dimer, hemorheology, coagulation form, and you may vein cystic. Overall, this research hold the use of high amounts of folic acid and supplement B12 to ease DVT.
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